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Activity Number: 343 - SPEED: Tests, Trials, Biomarkers, and Other Topics in Biometrics
Type: Contributed
Date/Time: Tuesday, July 31, 2018 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract #329292 Presentation
Title: Multiple Testing Procedure Consideration in Clinical Trials
Author(s): Rachael Wen*
Companies: Sanofi
Keywords: multiple testing procedure; clinical trial ; multiplicity ; correlation; hierarchical; power

Multiplicity adjustment is always a challenge to clinical trials, especially when there are complicate correlations and different clinical importance between the hypotheses. Here simulations are performed to compare the performance of different multiple testing procedures (MTPs): Hochberg procedure, weighted Bonferroni test, weighted parametric test, and gatekeeping procedure, etc. Based on the simulation results, some recommendations are made for MTP selection in clinical trial.

Authors who are presenting talks have a * after their name.

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