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Activity Number: 359 - Contributed Poster Presentations: Biopharmacutical Section
Type: Contributed
Date/Time: Tuesday, July 31, 2018 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract #329244
Title: Sample Size Calculation for a Pilot Study
Author(s): Danielle Sim* and Chi-Hong Tseng
Companies: UCLA and UCLA
Keywords: Sample size; Pilot study; Clinical trial; Power

One important aspect in the design of clinical studies is to determine the sample size such that there is sufficient power in detecting clinically meaningful treatment effect. A pilot study can help in estimating the variability of the outcome to provide realistic parameters in the design of main studies. In this paper, we present a method to calculate the sample size for the pilot study, such that the power calculation in the main will be realistic with adequate performance. We derive the pilot study sample size formula according to the desired performance of the main study and using simulations to demonstrate the performance of this method.

Authors who are presenting talks have a * after their name.

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