Robust Dose Response Estimation

• Activity Number: 37 - Statistical Issues Specific the Therapeutic Areas - 1
• Type: Contributed
• Date/Time: Sunday, July 29, 2018 : 2:00 PM to 3:50 PM
• Sponsor: Biopharmaceutical Section
• Author(s): Shouhao Zhou*
• Companies: University of Texas MD Anderson Cancer Center
• Keywords: dose response ; drug combination analysis; median-effect equation; robust estimation

Abstract

It is well-known that the drug combination analysis, based on the seminal work of median-effect approach of Chou and Talalay (1984), is sensitive to extreme values of dose response when applied to assess drug synergy in combination therapies. Here we propose a robust approach to estimate dose response curves. Simulation shows that the proposed method can significantly reduce the estimation bias and mean squared error.