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Activity Number:
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37
- Statistical Issues Specific the Therapeutic Areas - 1
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Type:
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Contributed
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Date/Time:
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Sunday, July 29, 2018 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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Abstract #329191
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Presentation
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Title:
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Robust Dose Response Estimation
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Author(s):
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Shouhao Zhou*
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Companies:
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University of Texas MD Anderson Cancer Center
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Keywords:
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dose response ; drug combination analysis; median-effect equation; robust estimation
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Abstract:
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It is well-known that the drug combination analysis, based on the seminal work of median-effect approach of Chou and Talalay (1984), is sensitive to extreme values of dose response when applied to assess drug synergy in combination therapies. Here we propose a robust approach to estimate dose response curves. Simulation shows that the proposed method can significantly reduce the estimation bias and mean squared error.
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Authors who are presenting talks have a * after their name.
