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Activity Number: 416 - Clinical Trial Design- 4
Type: Contributed
Date/Time: Tuesday, July 31, 2018 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract #329055 Presentation
Title: New Multiple Hypotheses Testing Procedures Based on Covering Principle
Author(s): Hong Zhou* and Huajiang Li
Companies: Arkansas State University and Avanir Pharmaceuticals
Keywords: Familywise error rate; multiple hypotheses testing; covering principle; closure principle; graphical method; gate-keeping

The converting principle has proposed recently to deal with the multiplicity issues when multiple hypotheses are tested simultaneously. New multiple testing procedures are constructed based on the covering principle by using the information among the rejection regions of hypotheses in the sample space. The new procedures can strongly control the familywise error rate. Applications of new procedures to real clinical trials are presented to illustrate how to use the new procedures. The simulation studies show that new procedures are more powerful than the widely used graphical approaches in some scenarios. In addition, the covering principle provides new solutions to the gate-keeping problems.

Authors who are presenting talks have a * after their name.

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