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Activity Number: 583 - Statistical Methods in Health Services and Performance Profiling
Type: Contributed
Date/Time: Wednesday, August 1, 2018 : 2:00 PM to 3:50 PM
Sponsor: Health Policy Statistics Section
Abstract #328944 Presentation
Title: Methods for Population-Adjusted Indirect Comparisons
Author(s): Joseph C Cappelleri*
Companies: Pfizer Inc
Keywords: meta-analysis; NICE; indirect comparisons; network meta-analysis; population adjustment; recommendations

Based on a NICE document (December 2016), this presentation highlights recommendations for use of population-adjusted indirect comparisons. These recommendations cover five areas: 1) the rationale for the use of population adjustment in NICE submissions, 2) justifying the use of population adjustment in both anchored and unanchored scenarios, 3) variables for which population adjustment is required, 4) generation of indirect comparison for the appropriate target population, and 5) reporting guidelines for analyses involving population adjustment. Research recommendations are given about the need for alternative approaches to population-adjusted indirect comparison and population-adjusted network meta-analysis intended to overcome the limitations of existing methods and, given this, the need for a plan on a comprehensive set of simulation studies, empirical studies, and illustrative applications of the new methods.

Authors who are presenting talks have a * after their name.

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