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Activity Number: 358 - Contributed Poster Presentations: Biometrics Section
Type: Contributed
Date/Time: Tuesday, July 31, 2018 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract #328912
Title: Analysis of Longitudinal Semicontinuous Data Using Marginalized Two-Part Model
Author(s): Miran Jaffa* and Mulugeta Gebregziabher and Ayad A Jaffa
Companies: American University of Beirut and Medical University of South Carolina and American University of Beirut
Keywords: Connective tissue growth factor; marginalized two-part model; one-part model; semicontinuous data; two-part model

We propose a novel application of the marginalized two-part model for longitudinal semicontinuous data in which the marginal mean is expressed in terms of the covariates to estimate their marginal interpretable effects. The continuous component is assumed to follow distributions that stem from the generalized gamma family whereas the binary measure is analyzed using logistic model, and are linked by correlated random effects to capture the within subject correlations. This study was motivated by our interest in determining the clinical parameters that affect the levels of connective tissue growth factor, a pathogenic risk factor for diabetic complications, measured longitudinally in type 1 diabetic patients.

Authors who are presenting talks have a * after their name.

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