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Activity Number:
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484
- Clinical Trial Design- 5
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Type:
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Contributed
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Date/Time:
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Wednesday, August 1, 2018 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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Abstract #328886
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Presentation
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Title:
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A Curtailed Two-Stage Selection and Testing Procedure for Comparative Clinical Trials
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Author(s):
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Mingyue Wang* and Pinyuen Chen
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Companies:
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Syracuse University and Syracuse University
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Keywords:
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Binomial Distribution;
Least Favorable Configuration;
Ranking and Selection;
Curtailment
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Abstract:
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We consider a two-stage selection and testing procedure which selects the t best of k (k > t > 1) experimental Bernoulli treatments and compares them to a control Bernoulli treatment. The procedure uses a curtailment for possible early decision which achieves the same significance level and power as those of non-curtailed procedure. We adopt the selection-and-testing design considered by Thall, Simon, and Ellenberg (1988), but with a different goal: selecting among k treatments the t (t < k) best treatments and to compare them to the control. The selection stage of the procedure selects the t best provided that they are significantly better than other experimental treatments and the control treatment. The testing stage tests whether the selected t treatments are superior to the control treatment. Numerical comparisons are presented to illustrate the savings of our curtailed procedure over the fixed-sample-size non-curtailed procedure.
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Authors who are presenting talks have a * after their name.
