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Activity Number: 484 - Clinical Trial Design- 5
Type: Contributed
Date/Time: Wednesday, August 1, 2018 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract #328886 Presentation
Title: A Curtailed Two-Stage Selection and Testing Procedure for Comparative Clinical Trials
Author(s): Mingyue Wang* and Pinyuen Chen
Companies: Syracuse University and Syracuse University
Keywords: Binomial Distribution; Least Favorable Configuration; Ranking and Selection; Curtailment

We consider a two-stage selection and testing procedure which selects the t best of k (k > t > 1) experimental Bernoulli treatments and compares them to a control Bernoulli treatment. The procedure uses a curtailment for possible early decision which achieves the same significance level and power as those of non-curtailed procedure. We adopt the selection-and-testing design considered by Thall, Simon, and Ellenberg (1988), but with a different goal: selecting among k treatments the t (t < k) best treatments and to compare them to the control. The selection stage of the procedure selects the t best provided that they are significantly better than other experimental treatments and the control treatment. The testing stage tests whether the selected t treatments are superior to the control treatment. Numerical comparisons are presented to illustrate the savings of our curtailed procedure over the fixed-sample-size non-curtailed procedure.

Authors who are presenting talks have a * after their name.

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