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Activity Number: 134 - Recent Development in Methods for Statistical Genetics
Type: Contributed
Date/Time: Monday, July 30, 2018 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistics in Genomics and Genetics
Abstract #328859 Presentation
Title: Pleiotropic Effects of Genetic Variants on Aging Traits and Lifespan: Applications of Stochastic Process Models
Author(s): Konstantin Arbeev* and Olivia Bagley and Fang Fang and Hongzhe Duan and Ilya Zhbannikov and Igor Akushevich and Alexander Kulminski and Svetlana Ukraintseva and Anatoliy Yashin
Companies: Duke University and Duke University and Duke University and Duke University and Duke University and Duke University and Duke University and Duke University and Duke University
Keywords: genetics; longevity; mortality; aging; pleiotropy; longitudinal data
Abstract:

Contemporary longitudinal studies often provide extensive genetic data in addition to information on time-to-event outcomes (such as mortality and onset of diseases) and repeated measurements of various biomarkers and other relevant health-related variables. This creates opportunities for finding genetic variants with individual and pleiotropic effects on various health traits, aging, and lifespan. In this work, we will discuss recent developments in the stochastic process model (SPM) methodology and related software (R package stpm; available on CRAN) which opened new avenues for applying this approach in large-scale analyses such as genome-wide association studies (GWAS). We will show how this approach can be used to evaluate pleiotropic effects of genetic variants on both longitudinal dynamics of biomarkers and risks of events and how the findings can be interpreted in the context of hidden characteristics of aging-related changes affecting these traits. We will illustrate applications of SPM to GWAS of longevity as well as to analyses of selected genes found in our earlier studies which revealed variants with pleiotropic effects on multiple aging-related traits and mortality.


Authors who are presenting talks have a * after their name.

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