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Activity Number: 233 - ASA Biometrics Section JSM Travel Awards (I)
Type: Topic Contributed
Date/Time: Monday, July 30, 2018 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract #327114
Title: A Semiparametric Approach to Model Effect Modification
Author(s): Muxuan Liang* and Menggang Yu
Companies: University of Wisconsin-Madison and University of Wisconsin-Madison
Keywords: Dimension reduction; Effect modification; Interaction; Semiparametric efficiency; Single and multiple index models

One fundamental statistical question for research areas such as precision medicine and health disparity is about discovering effect modification of treatment or exposure by observed covariates. We propose a semiparametric framework for identifying such effect modification. Instead of using the traditional outcome models, we directly posit semiparametric models on contrasts, or expected differences of the outcome under different treatment choices or exposures. Through semiparametric estimation theory, all valid estimating equations, including the efficient scores, are derived. Besides providing flexible models for effect modification, our approach also enables dimension reduction in presence of high dimensional data. The asymptotic and non-asymptotic properties of the proposed methods are explored via a unified statistical and algorithm analysis. Comparison with existing methods in both simulation and real data analysis demonstrates the superiority of our estimators especially for an efficiency improved version.

Authors who are presenting talks have a * after their name.

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