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Activity Number: 673 - Clinical Trial Design- 8
Type: Contributed
Date/Time: Thursday, August 2, 2018 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract #327012 Presentation
Title: Selecting Among Treatments with Two Bernoulli Endpoints
Author(s): Elena M Buzaianu* and Pinyuen Chen and Lifang Hsu
Companies: University of North Florida and Syracuse University and Le Moyne College
Keywords: Better Than A Standard; Two Endpoints; Correct Selection; Bernoulli Outcomes; Least Favorable Configuration; Worst Configuration

In phase II clinical trials, new treatments/therapies are studied relative to both treatment efficacy and safety. We propose a procedure for selecting a random size subset that contains all experimental treatments that are better than the standard. The comparison is with regard to two binary endpoints, in order to account for both treatment efficacy and safety. An experimental treatment is considered to be better than the standard if its two endpoints have successful rates higher than those associated with the standard. We derive the probability of a correct selection for our procedure and show that, whenever an experimental treatment is significantly better than the standard, our procedure achieves the probability requirements predetermined by the experimenter.

Authors who are presenting talks have a * after their name.

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