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Activity Number: 388 - Statistical and Computational Advances in Cancer Genomics with Application to Precision Medicine
Type: Invited
Date/Time: Tuesday, July 31, 2018 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Genomics and Genetics
Abstract #326550 Presentation
Title: Distinguishing Second Primary Cancers from Metastases: Statistical Challenges in Testing Clonal Relatedness of Tumors
Author(s): Colin B Begg*
Companies: Memorial Sloan Kettering Cancer Center

The pathological diagnosis of a new tumor in a patient with an existing or previous cancer can be challenging for pathologists in certain clinical settings. Modern techniques for molecular analysis of the two tumor specimens to detect common somatic changes offers the promise of more accurate classification of the second tumor as either a metastasis or a second independent primary. In the past few years our group has examined how to construct statistical tests for clonal relatedness in this setting using the somatic profiles of the tumors. This work has evolved as the genetic technologies available have evolved. Some of the challenges and results will be presented.

Authors who are presenting talks have a * after their name.

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