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Activity Number: 388 - Statistical and Computational Advances in Cancer Genomics with Application to Precision Medicine
Type: Invited
Date/Time: Tuesday, July 31, 2018 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Genomics and Genetics
Abstract #326512 Presentation
Title: Tumor Heterogeneity in Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
Author(s): Ruibin Xi*
Companies: Peking University
Keywords: subclone; high-throughtpu sequencing; precision medice; targetable mutation

Tumor heterogeneity is an emerging theme that we only start to understand recently. Many human tumors display genetic and epigenetic heterogeneity. These heterogeneities may have important implications in tumor progression, therapeutic effect and tumor prognosis. Here, we used multi-regional exome sequencing to study the tumor heterogeneity of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Our analysis revealed that HCC and ICC tumors have significant genetic heterogeneity. For many patients, the tumor cells from different regions often have different sets of targetable mutations. Further experimental analysis show that these subregional tumors respond differently to target therapies due to their genetic heterogeneity.

Authors who are presenting talks have a * after their name.

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