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Activity Number: 100 - Optimizing Medical Decision Making with Real World Evidence
Type: Invited
Date/Time: Monday, July 30, 2018 : 8:30 AM to 10:20 AM
Sponsor: ENAR
Abstract #325463
Title: Shared-Parameter G-Estimation of an Optimal Adaptive Treatment Strategy for Rheumatoid Arthritis
Author(s): Erica E.M. Moodie and Michael Wallace*
Companies: McGill University and University of Waterloo
Keywords: Adaptive treatment strategies; Dynamic treatment regimes; G-estimation; Doubly robust; Personalized medicine

The doubly-robust method of G-estimation can be used to estimate used an adaptive treatment strategy in which parameters are shared across different stages of the treatment sequence, allowing for more efficient estimation and simpler treatment decision rules. The approach is computationally stable, and produces consistent estimators provided either the outcome model or the treatment allocation model is correctly specified. In this talk, the method will be demonstrated in the context of the treatment of rheumatoid arthritis, a chronic inflammatory condition which can require ongoing treatment.

Authors who are presenting talks have a * after their name.

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