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Activity Details

CE_10C Sun, 7/30/2017, 8:30 AM - 5:00 PM H-Key Ballroom 12
Precision Medicine Through Optimal Treatment Regimes (ADDED FEE) — Professional Development Continuing Education Course
ASA , Biometrics Section
The vision for precision medicine is a healthcare system that adapts to the uniquely evolving health status of each individual patient. Such a system can deliver interventions only if, when, and in the amount they are needed thereby improving patient outcomes while reducing resource expenditures. Treatment regimes operationalize precision medicine as a sequence of decision rules, one per stage of intervention, that map up-to-date patient information to a recommended treatment. An optimal treatment regime maximizes the mean of some cumulative clinical outcome if applied to select treatments in a population of interest. In this course, we provide a rigorous but accessible introduction to estimation of and inference for optimal treatment regimes using data from observational or randomized studies. Topics covered include: formalizing an optimal treatment regime using potential outcomes; regression-based and policy-search estimators of an optimal treatment regime; design and analysis of sequential multiple assignment randomized trials; asymptotic methods for statistical inference; and software for constructing and evaluating estimated optimal treatment regimes. No prior exposure to treatment regimes is assumed
Instructor(s): Eric Laber, North Carolina State University, Marie Davidian, North Carolina State University, Anastasios (Butch) Tsiatis, North Carolina State University, Shannon Holloway, North Carolina State University
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