Abstract:
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In clinical trials, assay measurement platforms are developed for the cutting-edge drug discovery. Subsequent to the development of a highly sensitive and specific LCMS-based platform, a higher throughput and more cost effective immunoassay platform was recently initiated. To evaluate if the measurements from the immunoassay platform were generally comparable to those of the LCMS platform, data from 2 studies were analyzed in which the measurements from both the new and old platforms were available across several visits for each subject. This presentation compares statistical methods used to estimate the correlation coefficient between two measures in settings where multiple observations are available on the same subject. Specifically, the correlation coefficient with repeated measurements and the concordance correlation coefficient with repeated measurements will be discussed and applied to the data sets. A simulation study will be performed to further assess the performance of these methods.
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