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Activity Number:
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42
- A Cornecopia of Statistics
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Type:
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Contributed
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Date/Time:
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Sunday, July 30, 2017 : 2:00 PM to 3:50 PM
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Sponsor:
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General Methodology
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Abstract #325004
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Title:
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Clustering Adult Cystic Fibrosis and Chronic Obstructive Pulmonary Disease Patients Based on Lung Function Dynamics
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Author(s):
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Barbara Bailey*
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Companies:
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San Diego State University
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Keywords:
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Abstract:
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Adult patient longitudinal lung function data are used to describe and characterize the dynamics of lung function over time. We fit quantile splines and estimate the rate of change of the lung function over time. The estimated derivatives, along with corresponding summary statistics are used for patient clustering. Informative groupings are identified using a proximity matrix generated by unsupervised Random Forests and clustering by Partitioning around Medoids (PAM). Classes were created from variables that capture the dynamics of these curves in both cohorts. We demonstrate the feasibility and utility of measuring FEV1 dynamics in representative cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) populations.
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Authors who are presenting talks have a * after their name.
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