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Activity Number: 42 - A Cornecopia of Statistics
Type: Contributed
Date/Time: Sunday, July 30, 2017 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics and the Environment
Abstract #324761
Title: Very High Energy Particle-Beam and Gamma Radiation Exposure and Familial Relatedness in Mice
Author(s): Mark P Little* and Pavel Chernyavskiy and Elijah Edmondson and Michael Weil
Companies: National Cancer Institute and National Cancer Institute and Frederick National Laboratory for Cancer Research and Colorado State University
Keywords: leukemia ; lung cancer ; random effects model ; Cox model ; familial clustering ; space radiation exposure
Abstract:

There are various highly-penetrant familial cancer syndromes with elevated leukemia risk, and evidence for familial clustering of other common cancers. Myeloid leukemia is highly radiogenic, but there is little evidence that induction by high-energy irradiation, typical of radiation exposures in outer space, is markedly more effective than low-energy radiation. We used a Cox model with familially-structured random effects to assess fifteen separate cancer endpoints, in a group of 1850 mice in 47 families maintained in a circular breeding scheme, exposed to accelerated high energy silicon-28 (Si) (240 MeV) or iron-56 (Fe) (600 MeV) ions, or cesium-137 gamma-rays. There is periodicity in the effect of familial relatedness, which is most pronounced for pulmonary adenoma, Harderian-gland adenoma, Harderian-gland tumor, ectodermal tumor, pulmonary adenocarcinoma and hepatocellular carcinoma (p=0.0001/0.0003/0.0017/0.0035/0.0257/0.0340 respectively) with families that are 3-4 generations apart most strongly correlated; myeloid leukemia also exhibited a striking periodic correlation structure. The effects per unit dose of high-energy beams are less than 9 x those of lower energy gamma.


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