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Activity Number: 462 - SPEED: Survey Research Methods
Type: Contributed
Date/Time: Wednesday, August 2, 2017 : 8:30 AM to 10:20 AM
Sponsor: Survey Research Methods Section
Abstract #324725
Title: Effect Modifications of Blood Lead-Cardiovascular Disease Mortality Association by Time-Related Factors Studied Using NHANES Linked Mortality Files
Author(s): Yutaka Aoki* and Jennifer Parker
Companies: National Center for Health Statistics and National Center for Health Statistics
Keywords: cardiovascular disease mortality ; survival analysis ; NHANES ; biomarker ; Cox regression
Abstract:

We previously reported that age-specific mortality of participants in the National Health and Nutrition Examination Survey (NHANES) 1999-2010 differed by survey cycle (better survival for later survey cycles), which was attributed to the longer followup time for early survey cycles rather than a true secular trend. In the current work, using Cox regression, we explore alternative methods to adjust for the followup time-mortality association, which was found to be more pronounced for older age during followup, in the analysis of blood lead and cardiovascular disease (CVD) mortality. We examined whether time-related factors including followup time (and its functions interacted with age during followup), age at followup start, calendar time at followup start, age during followup, and calendar time during followup) operate as effect modifiers of the blood lead-CVD mortality association. Our preliminary analyses indicate that the time-related factors are not effect modifiers of blood lead-CVD mortality association.


Authors who are presenting talks have a * after their name.

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