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Abstract:
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Dudbridge and Koleman (2003) studied the rank truncated product method (RTP) for combining P-values in genetic research, where the smallest K values of potentially large L number of P-values are combined. RTP was independently developed by us and gained popularity in various extensions, including adaptive variations where K is chosen in a way to maximize power. However, the theoretical form of the RTP distribution is unwieldy and involves a complicated multiple integration. We recently developed new ways of evaluating its distribution that simplifies substantially the analytic form of the combined P-value, down to a single line of R code. We will discuss implications of this development including potential directions for future research.
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