Online Program Home
  My Program

Abstract Details

Activity Number: 605 - Recent Statistical Advance in Functional Genomics
Type: Topic Contributed
Date/Time: Thursday, August 3, 2017 : 8:30 AM to 10:20 AM
Sponsor: ENAR
Abstract #324597 View Presentation
Title: Functional Impact of Epigenomic Variation Between Individuals
Author(s): Kasper Hansen*
Companies: Johns Hopkins Biostatistics
Keywords: Epigenomics ; Genomics

Functional genomics have provided epigenomic profiles on many distinct cell types, typically cell lines. For this reason, we have limited understanding of the functional impact of biological variation in many epigenomic marks, specifically histone modifications. Using recently generated publicly available data we have addressed this question for a set of common modifications. We find that epigenomic variation is associated with functional variation for some, but not all, loci. We investigate the use of multiple null distributions and show that even control experiments can be significantly associated with gene expression. Finally, we use ATAC sequencing and DNA methylation to understand epigenomic variation in the human brain.

Authors who are presenting talks have a * after their name.

Back to the full JSM 2017 program

Copyright © American Statistical Association