Online Program Home
  My Program

Abstract Details

Activity Number: 242 - Contributed Poster Presentations: Biometrics
Type: Contributed
Date/Time: Monday, July 31, 2017 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract #324465
Title: Detecting Trend in Mean of a Continuous Response: Towards a Default Procedure for Toxicological Dose-Response Applications
Author(s): David Farrar*
Companies: US EPA
Keywords: Trend Test ; Dose Response ; Toxicology
Abstract:

Results from tests for dose-response trend are often used to support conclusions on toxicity of a substance, which may lead to quantitative use of the dose-response curve. A substantial literature has developed, comparing alternative trend tests. Here, power comparisons are displayed for some single- and multiple-contrast tests for trend in mean response for a 5-group design, an assortment of monotone curve shapes, and a maximum effect (compared to controls) equal to 1 within-group standard deviation. We implement a simple algorithm for generating a diverse array of curve shapes. Resort to basic Monte Carlo simulation is avoided due to advances in multiple numerical integration as implemented in current software. Our results are consistent with previously-reported results with respect to dependence of relative sensitivity of alternative tests on curve shape. However, such results may at least narrow the selection of a default procedure.


Authors who are presenting talks have a * after their name.

Back to the full JSM 2017 program

 
 
Copyright © American Statistical Association