|
Activity Number:
|
455
- Oncoimmunology Gene Networks: Parallel Data Studies of Multi-Tissue Network Analysis
|
|
Type:
|
Topic Contributed
|
|
Date/Time:
|
Wednesday, August 2, 2017 : 8:30 AM to 10:20 AM
|
|
Sponsor:
|
Biometrics Section
|
|
Abstract #324191
|
|
|
Title:
|
Regulation of Cancer Testis Antigen Rich Whole Transcriptome Profiling of Ovarian Tumors
|
|
Author(s):
|
Kevin H Eng* and Wenjun He and Kayla Morrell and Anthony Milliotto and Kunle Odunsi
|
|
Companies:
|
Roswell Park Cancer Institute and Roswell Park Cancer Institute and Roswell Park Cancer Institute and Roswell Park Cancer Institute and Roswell Park Cancer Institute
|
|
Keywords:
|
Immunology ;
Genomics ;
Gene Expression ;
Multi-tissue
|
|
Abstract:
|
Ovarian cancers are known to possess a variable level of immunogenicity - some tumors generate a high level of immune infiltration while others do not. Importantly, the degree of immune infiltration is strongly prognostic: it is better to have a tumor that is seen and fought by the immune system. To understand the transcriptomic pattern underlying this response, we assayed the transcriptome of 69 tumors and further isolated components of the immune compartment and assayed these tumor infiltrating lymphocytes (TILs). A matched ascites sample provided a tumor associated lymphocyte (TAL) sample for the characterization of a distal, cancer related immune response. This immunogenic response may be related to the expression of endogenous tumor antigen and we focus on the family of cancer testis (CT) antigens that present only in dysregulated transformed tissue. Noting that many CT antigens co-express together, we pre-selected tumors that expressed NY-ESO-1 and other antigens -- "CT rich" tumors versus tumors that expressed no antigen. We expect many future studies will be required to characterize both a tumor and immune compartment and provide discussion on design and analysis.
|
Authors who are presenting talks have a * after their name.
