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Activity Number:
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606
- Meta-Analysis Has Moved Beyond Its Original Niche as a Method to Provide a Summary of the Average Effect of an Intervention on an Outcome
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Type:
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Topic Contributed
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Date/Time:
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Thursday, August 3, 2017 : 8:30 AM to 10:20 AM
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Sponsor:
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Section on Statistics in Epidemiology
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Abstract #323608
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Title:
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Robust Network Meta-Analysis: a Confidence Distribution Approach
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Author(s):
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Dungang Liu* and Guang Yang and Minge Xie
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Companies:
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University of Cincinnati and Jet.com and Rutgers University
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Keywords:
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Confidence distribution ;
Evidence-based medicine ;
Evidence synthesis ;
meta-analysis ;
robustness ;
multivariate analysis
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Abstract:
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One of the challenges in network meta-analysis is how to effectively and efficiently integrate information when each of the studies only provides partial information for the multiple parameters (treatments). In this talk, we propose a general framework for network meta-analysis. The general idea is to combine multivariate confidence distribution (CD) functions, which can be viewed as frequentist "distribution estimates" of the unknown parameters. We show that the proposed CD framework yields 1) an efficient combination when the evidence is consistent? and 2) robust combinations when the population of the studies is contaminated. The properties of efficiency and robustness are illustrated using numerical examples.
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Authors who are presenting talks have a * after their name.
