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Activity Number: 291 - SPEED: Biopharmaceutical Statistics
Type: Contributed
Date/Time: Tuesday, August 1, 2017 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract #323061 View Presentation
Title: Power Comparison of Tests of Restricted Mean Survival Time with Log-Rank Test and Generalized Wilcoxon Test Under Various Survival Distributions
Author(s): Musashi Fukuda* and Yutaka Matsuyama
Companies: Astellas Pharma Inc. and Department of Biostatistics, School of Public Health, The University of Tokyo
Keywords: restricted mean survival time ; log-rank test ; generalized Wilcoxon test ; non-proportional hazard ; power
Abstract:

Restricted mean survival time (RMST) is attracting attention as an easily interpretable effect measures both with and without proportional-hazard (PH) assumption. However operational characteristics of RMST as a test statistic compared with log-rank test or other rank-type tests are unclear. In this research, we evaluate the power of Wald test of RMST difference and ratio in comparison with log-rank test and generalized Wilcoxon test under various survival distributions with and without PH assumption. We simulate PH-effect, early-effect and delayed-effect type of clinical trials under the Weibull models, piecewise-exponential models, log-logistic-accelerated failure time models and location-scale models. We found the power of RMST was similar to that of generalized Wilcoxon test under most of all scenarios.


Authors who are presenting talks have a * after their name.

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