Activity Number:
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216
- Statistical Opportunities in Disease Interception: Screening, Intervening, and Evaluating Benefit-Risk Trade-Offs
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Type:
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Topic Contributed
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Date/Time:
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Monday, July 31, 2017 : 2:00 PM to 3:50 PM
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Sponsor:
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Section on Medical Devices and Diagnostics
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Abstract #322805
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View Presentation
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Title:
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Alzheimer's Intervention Case Study: Patient Preferences and Benefit-Risk Tradeoffs in Interception of Alzheimer's Disease
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Author(s):
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Rachael L. DiSantostefano* and Shelby Reed and Reed Johnson and Jui-Chen Yang and Johannes Streffer and Bennett Levitan
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Companies:
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Janssen R&D and Duke University and Duke University and Duke University and Janssen R&D and Janssen R&D
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Keywords:
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preferences ;
benefit-risk ;
screening ;
latent class analysis
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Abstract:
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Background: Biomarkers allow for the early identification and treatment of Alzheimer's Disease (AD) before the onset of symptoms, but may result in longer treatment and associated side effects. Objectives: To investigate heterogeneity of expressed preferences for treatment benefits and risks for delaying the onset of AD symptoms. Methods: Older US adults (n=1004) completed a web-enabled discrete-choice survey where they were to suppose that they would develop AD in the future without medication based on a screening test. Choice tasks presented the option of no treatment vs. a hypothetical AD treatment that would extend time w/ normal memory combined with adverse effects. Choice data were analyzed using scale-adjusted latent-class analysis (LCA). Results: Most participants (66%) were willing to accept relatively high risks of treatment-related stoke and death in the first year of treatment (mean 8-16%) in exchange for 1-2 more years of normal memory. LCA revealed 3 distinct preference classes where membership was correlated with patient characteristics. Conclusions: LCA results are useful to detect heterogeneity of preferences for early disease interception following screening.
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Authors who are presenting talks have a * after their name.