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Activity Number: 317 - Integration Approaches and Methods for Deciphering Genotype-Phenotype Mapping Toward Precision Medicine
Type: Invited
Date/Time: Tuesday, August 1, 2017 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistics in Genomics and Genetics
Abstract #322267 View Presentation
Title: Confidence Intervals for Heritability via Haseman-Elston Regression
Author(s): Tamar Sofer*
Companies: University of Washington, Department of Biostatistics
Keywords: Variance components ; proportions of variance ; quadratic forms ; meta-analysis ; eigenvalues

Heritability is the proportion of phenotypic variance in a population that is attributable to individual genotypes. In population-based genome-wide association studies (GWAS), mixed models are used to estimate variance components, from which a heritability estimate is obtained. The estimated heritability is the proportion of the model's total variance that is due to the genetic relatedness matrix (kinship measured from genotypes). Current practice is to use bootstrapping, which is slow, or normal asymptotic approximation to estimate the precision of the heritability estimate; however, this approximation fails to hold near the boundaries of the parameter space or when the sample size is small. In this paper we propose to estimate variance components via a Haseman-Elston regression, find the asymptotic distribution of the variance components and proportions of variance, and use them to construct confidence intervals (CIs). Our method is further developed to estimate unbiased variance components and construct CIs by meta-analyzing information from multiple studies. We demonstrate our approach on data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Authors who are presenting talks have a * after their name.

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