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Activity Number: 145 - Statistical Methods in Data Integration and Data Harmonization
Type: Invited
Date/Time: Monday, July 31, 2017 : 10:30 AM to 12:20 PM
Sponsor: ENAR
Abstract #322168 View Presentation
Title: Meta-Analysis with Extremely Small Number of Studies
Author(s): Lu Tian* and Minge Xie and LJ Wei
Companies: Stanford University and Rutgers University and Harvard University
Keywords: meta analysis ; random effect model ; exact inference
Abstract:

Meta analysis is a popular tool to synthesize evidence from multiple sources. In the presence of study heterogeneity, the random effects model is the commonly used statistical model for meta analysis. There are two major limitations for the statistical inference based on the random effects model: the dependence on the restricted parametric assumption and the asymptotic justification requiring large number of studies. When the number of studies is moderate or large, some exact inference procedures have been developed. However, when the number of study is less than 6, current methods are either inapplicable or invalid. We feel that if only a very small number of studies are available for meta analysis, then appropriate parametric assumptions are unavoidable in order to effectively summarize the data. In this talk we propose an exact inference procedure for parametric random effects model, which is valid regardless of the number of studies. We will illustrate the new proposal with both simulation study and real data example.


Authors who are presenting talks have a * after their name.

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