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Activity Number: 312 - SAMSI-CCNS: Innovations and Challenges in Computational Neuroscience
Type: Invited
Date/Time: Tuesday, August 1, 2017 : 10:30 AM to 12:20 PM
Sponsor: International Indian Statistical Association
Abstract #322073
Title: A LAG FUNCTIONAL LINEAR MODEL for PREDICTION of MAGNETIZATION TRANSFER RATIO in MULTIPLE SCLEROSIS LESIONS
Author(s): Gina-Maria Pomann* and Ana-Maria Staicu and Edgar Lobaton and Amanda Mejia and Blake Dewey and Daniel Reich and Elizabeth M. Sweeney and Russell Shinohara
Companies: Duke University and North Carolina State University, Department of Statistics and North Carolina State University and Indiana University and NINDS and NINDS and Flatiron Health and University of Pennsylvania
Keywords: Functional Data Analysis ; Structural MRI
Abstract:

We propose a lag functional linear model to predict a response using multiple functional predictors observed at discrete grids with noise. Two procedures are proposed to estimate the regression parameter functions: 1) an approach that ensures smoothness for each value of time using generalized cross-validation; and 2) a global smoothing approach using a restricted maximum likelihood framework. Numerical studies are presented to analyze predictive accuracy in many realistic scenarios. The methods are employed to estimate a magnetic resonance imaging (MRI)-based measure of tissue damage (the magnetization transfer ratio, or MTR) in multiple sclerosis (MS) lesions, a disease that causes damage to the myelin sheaths around axons in the central nervous system. Our method of estimation of MTR within lesions is useful retrospectively in research applications where MTR was not acquired, as well as in clinical practice settings where acquiring MTR is not currently part of the standard of care. The model facilitates the use of commonly acquired imaging modalities to estimate MTR within lesions, and outperforms cross-sectional models that do not account for temporal patterns of lesions.


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