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Abstract:
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R. A. Fisher, the father of modern statistics, proposed the idea of fiducial inference in the 1930's. While his proposal led to some interesting methods for quantifying uncertainty, other prominent statisticians of the time did not accept Fisher's approach because it went against the ideas of statistical inference of the time. Beginning around the year 2000, the presenter and collaborators started to re-investigate the idea of fiducial inference and discovered that Fisher's approach, when properly generalized, would open doors to solve many important and difficult inference problems. They termed their generalization of Fisher's idea as generalized fiducial inference (GFI). After more than a decade of investigations, the presenter and collaborators have developed a unifying theory for GFI and provided GFI solutions to many challenging practical problems in different fields of science and industry. Overall, they have demonstrated that GFI is a valid, useful, and promising approach for conducting statistical inference. In this presentation, we will discuss several applications of GFI and related approaches to biological data analysis including RNAseq data and its variants.
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