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Activity Number: 464
Type: Invited
Date/Time: Wednesday, August 3, 2016 : 8:30 AM to 10:20 AM
Sponsor: ASA
Abstract #321841
Title: Bayesian Adaptive Designs
Author(s): Scott Berry*
Companies: Berry Consultants

In this section we will explore the current state of the industry for adaptive designs. A focus will be on exploring applied trial designs.

In this talk a wide range of adaptive trial designs will be explored. These trial designs will be from a wide range of development stages as well as therapeutic areas. This will include innovative customized CRM trials for phase I, response adaptive dose-finding phase II trials, basket trials in phase II and phase III as well as adaptive trials for pivotal trials. A discussion of seamless trials will be presented as well.

Specific Discussion Topics will be:  The role of Bayesian and frequentist aspects will be addressed.  The role of simulation in adaptive trials  Regulatory Interactions  Operational Issues

Specific adaptive and modeling aspects Discussed will be  Response Adaptive Randomization  Enrichment Modeling  Posterior/Predictive Distributions  Longitudinal Modeling  Dose-Response Modeling  Stopping for success  Stopping for futility  Adaptively selecting sample size

Authors who are presenting talks have a * after their name.

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