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Activity Number:
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554
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 3, 2016 : 10:30 AM to 12:20 PM
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Sponsor:
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Scientific and Public Affairs Advisory Committee
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Abstract #320887
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Title:
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Grouping Engineered Nanomaterials by Pulmonary Toxicity Using Rodent Dose-Response Relationships
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Author(s):
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Nathan Drew* and Eileen D. Kuempel
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Companies:
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National Institute for Occupational Safety and Health and National Institute for Occupational Safety and Health
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Keywords:
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benchmark dose ;
nanomaterial ;
pulmonary inflammation
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Abstract:
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The large and rapidly growing number of engineered nanoparticles presents a major challenge to obtaining adequate data to assess the potential health risk of occupational exposure to airborne engineered nanomaterials (ENMs). A database consisting of 25 in vivo rodent studies and 1,929 animals across various experimental designs and material types was constructed in order to identify similar materials with respect to their potency in eliciting pulmonary inflammation. Potency was defined as the inverse of the estimated mass deposited lung dose associated with 10% polymorphonuclear leukocyte cells in the lungs, a biologically significant response. These doses were estimated by modeling the continuous dose-response relationships using the US EPA Benchmark Dose Software v. 2.6, and hierarchical clustering was used to identify similar materials. The acute pulmonary inflammation potencies of fourteen ENMs (0-3 days after exposure) across three groups were approximately five to 140 times greater than that of a microscale particle in a fourth group. Random forest methods were used to identify the important factors in each group for predicting the pulmonary toxicity of new ENMs.
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Authors who are presenting talks have a * after their name.
