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Activity Number:
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660
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Type:
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Contributed
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Date/Time:
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Thursday, August 4, 2016 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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Abstract #320727
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Title:
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Efficient Study Designs in Clinical Research
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Author(s):
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Steven Julious*
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Companies:
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University of Sheffield
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Keywords:
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Clinical trials ;
Efficient study design ;
Adaptive Designs
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Abstract:
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In the current research environment there is a need to answer ever more important clinical questions while the resources that are not increasing or even falling. Efficient study designs have the potential to enable the questions to be answered while making optimal use of finite resources. Efficient designs are defined as "statistically robust" designs that enable quicker and/or lower cost decisions compared to a conventional design. An efficient design is an umbrella term which encompasses all aspects of clinical trials as well as the design. Efficient designs are in fact a "smarter" ways of conducting a trial. By being efficient resources and time can be saved in the assessment of new health technologies. Through a series case studies the benefits of efficient study designs will be highlighted. For example: The PLEASANT trial used routinely collected data for data collection and was approximately £1.5 million cheaper; retrospective analysis of RATPAC as a group sequential showed that if the trial had been adaptive it would have $400,000; An audit of public funded trials suggested that futility assessments would increase successfully recruiting trials from 45% to 64%.
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Authors who are presenting talks have a * after their name.
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