Online Program Home
My Program

Abstract Details

Activity Number: 339
Type: Topic Contributed
Date/Time: Tuesday, August 2, 2016 : 10:30 AM to 12:20 PM
Sponsor: WNAR
Abstract #320526
Title: Integrated DNA Mutation, Copy Number, and Gene Expression Analysis Reveals a Highly Reproducible Prognostics Marker in Lung Adenocarcinomas
Author(s): Hao Ho*
Companies: University of California at Los Angeles
Keywords: Liquid Association ; Cancer study ; Integrative data analysis ; Copy number ; Gene expression

In cancer genome, mutation and copy number alteration (CNA) are important regulators of gene expression. Many of the existing methods are limited by omitting nonlinear effects. We proposed a novel approach adopting a modified liquid association (LA) score to explore the complex interaction effects. Liquid association score was introduced to measure the average change in the covariation of two variables as a third continuous variable varies. A modified LA score was designed for studying the change of effect between copy number and gene expression conditioned on different mutation status as a binary variable. We applied our method using EGFR mutation status as a master regulator alone with genome-wide copy number and gene expression of 159 lung adenocarcinomas from National Taiwan University Hospital and Taichung Veterans General Hospital. Our method revealed four EGFR mutant/wild-type specific conditional CNA-correlated differentially expressed genes. Using the Cox proportional hazards model, we identified one gene's over-expression is associated with poor overall survival and this result was validated in three independent cohorts.

Authors who are presenting talks have a * after their name.

Back to the full JSM 2016 program

Copyright © American Statistical Association