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Activity Number: 611
Type: Contributed
Date/Time: Wednesday, August 3, 2016 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract #319817 View Presentation
Title: Bias Reduction in Logistic Regression with Missing Responses When the Missing-Data Mechanism Is Nonignorable
Author(s): Vivek Pradhan* and Arnab Maity
Companies: Pfizer and Northern Illinois University
Keywords: Nonignorable missing ; Missing binary response ; Firth correction ; EM algorithm ; Separation
Abstract:

In binomial logistic regression with non-ignorable missing responses, Ibrahim and Lipsitz (1996) proposed a method for estimating regression parameters. It is known that the regression estimates obtained by using this method are biased when the sample size is small. Also, another complexity arises when the iterative estimation process encounters separation in estimating regression coefficients. In this article, we propose a method to improve the estimation of regression coefficients. In our likelihood based method, likelihood is penalized by multiplying a non-informative Jeffreys prior as a penalty term. The proposed method reduces bias and is able to handle the issue of separation. Simulation results show the substantial bias reduction of the proposed method as compared to the existing method. Analyses using real world data also support the simulation findings.


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