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Activity Number: 420
Type: Topic Contributed
Date/Time: Tuesday, August 2, 2016 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Imaging
Abstract #319023
Title: Optimal Correlation Detection with Application to Colocalization Analysis in Dual-Channel Fluorescence Microscopic Imaging
Author(s): Shulei Wang* and Jianqing Fan and Ming Yuan
Companies: University of Wisconsin - Madison and Princeton and University of Wisconsin
Keywords: signal detection ; colocalization ; structured multiple testing ; optimal rate
Abstract:

Motivated by the problem of colocalization analysis of fluorescence microscopic imaging, we study in this paper structured detection of correlation regions between two random processes observed on a common domain. We introduce a size-based normalization for the likelihood ratio statistics and show that scanning with this normalized statistics leads to optimal correlation detection over a large collection of structured correlation detection problems.


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