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                        | Activity Number: | 178 |  
                        | Type: | Contributed |  
                        | Date/Time: | Monday, August 1, 2016 : 10:30 AM to 12:20 PM |  
                        | Sponsor: | Biopharmaceutical Section |  
                        | Abstract #318888 |  |  
                        | Title: | A Bayesian Approach for Classification Based on Continuous Glucose Monitoring Data of Diabetic Patients |  
                    | Author(s): | Hui Zheng* |  
                    | Companies: | Harvard Medical School |  
                    | Keywords: | Bayesian  ; 
                            Spline ; 
                            classification ; 
                            continuous glucose monitoring ; 
                            diabetes ; 
                            CGM |  
                    | Abstract: | 
                            We propose a Bayesian modeling approach to distinguish subgroups of diabetic patients based on their glucose profiles. The glucose data are collected using continuous glucose monitoring (CGM) devices which measure glucose at a frequency of once 1 to 5 minutes. The classification method is based on a hierarchical model using B-spline basis functions to smooth the glucose measurements while allowing for auto-correlations. In the training phase, the mean and variance-covariance matrices of glucose profiles are obtained for each subgroup. The classification is based the posterior probabilities for a patient to belong to each subgroup. We illustrate the method using CGM data collected in a clinical trial .   
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