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Activity Number:
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428
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Type:
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Contributed
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Date/Time:
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Tuesday, August 2, 2016 : 2:00 PM to 3:50 PM
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Sponsor:
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Biometrics Section
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Abstract #318729
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View Presentation
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Title:
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Using IMRE and Dual KS to Select MicroRNAs for Predicting Prostate Cancer
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Author(s):
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Yarong Yang*
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Companies:
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North Dakota State University
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Keywords:
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microRNA ;
Prostate Cancer ;
gene expression
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Abstract:
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Imputed microRNA regulation based on weighted ranked expression and putative microRNA targets (IMRE) is a method of predicting microRNA regulation from genome-wide gene expression as well as predicting microRNA putative targets. A false discovery rate for each microRNA is calculated using the expression of the microRNA putative targets to analyze the regulation between different conditions. Dual KS is an efficient analytic methodology that can identify class specific highly parsimonious gene signatures. We apply the IMER and Dual KS methods on a prostate cancer gene expression dataset with 596 men of three different phenotypes: PSA (Prostate-Specific Antigen recurrence), Systemic (Systemic disease progression) and NED (No Evidence of Disease). A group of microRNAs are selected for experimental tests for the PSA recurrence and Systemic disease progression.
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Authors who are presenting talks have a * after their name.
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