Abstract:
|
Point-of-care randomized clinical trials aim to generate evidence on the comparative effectiveness of interventions that are already in use in routine care. In this talk, we will give an overview of design challenges for such trials and some innovative approaches that have been proposed in the literature to address these challenges, including (1) outcome adaptive randomization to address the objective of treating accrued patients with the best (yet known) interventions; (2) adaptive designs to address questions which evolve sequentially about the interventions, either endogenously during the course of the trial or exogenously from the changing landscape of medical knowledge and practice; (3) adaptive designs to jointly develop and test treatment strategies for subpopulations.
|