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Activity Number: 283
Type: Invited
Date/Time: Tuesday, August 2, 2016 : 8:30 AM to 10:20 AM
Sponsor: ENAR
Abstract #318019 View Presentation
Title: Adaptive Treatment Allocations for Emerging Infectious Diseases
Author(s): Eric Laber* and Nicholas Meyer and Brian J. Reich and Krishna Pacifici and Tao Hu
Companies: North Carolina State University and North Carolina State University and North Carolina State University and North Carolina State University and North Carolina State University
Keywords: Precision medicine ; Dynamic treatment regimes ; Disease modeling ; Semi-parametric estimation ; Optimization

A key component in controlling the spread of an epidemic is deciding where, when, and to whom to apply an intervention. We conceptualize the epidemic as spreading across nodes in an network. A treatment allocation strategy formalizes this process as a sequence of functions, one per treatment period, that map up-to-date information on the epidemic to a subset of nodes to receive treatment. An optimal treatment allocation strategy minimizes the expectation of some cumulative measure of harm, e.g., the number of infected individuals, the geographic footprint of the disease, or the estimated total cost of the disease. One approach to estimating an optimal allocation strategy is to model the underlying disease dynamics and then use to simulation---optimization. However, constructing a high-quality estimator of the system dynamics is difficult especially in the context of emerging epidemics where there is little scientific theory to inform a class of models. We derive estimating equations for the optimal allocation strategy that does not require a model the system dynamics. As this estimator does not require simulation, it is computationally tractable for massive problems.

Authors who are presenting talks have a * after their name.

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