JSM 2015 Preliminary Program

Online Program Home
My Program

Abstract Details

Activity Number: 194
Type: Contributed
Date/Time: Monday, August 10, 2015 : 10:30 AM to 12:20 PM
Sponsor: ENAR
Abstract #317947
Title: Risk Factors and Outcomes in a Multiple Tumor Marker Setting: The Issues of Correlated and Missing Tumor Markers
Author(s): Bernard Rosner* and Kathryn Fitzgerald
Companies: Brigham and Women's Hospital and Harvard School of Public Health
Keywords: Breast cancer ; competing risks ; proportional hazards model ; missing data ; multiple imputation ; inverse probability weighting
Abstract:

Risk profiles for cancer outcomes often vary by the presence of different tumor markers or subtypes. Increasing the number of markers adds an additional layer of complexity as markers are often correlated, and as a result, leads to difficulty in assessing subtype-specific effects of particular risk factors without considering other markers. Scientifically, it's also of interest to identify which marker or combination of markers is most relevant for disease. Finally, with a larger number of markers, the likelihood of missing marker information also increases and raises the question as to how to properly address this issue. In this paper, we apply methodology originally introduced by Rosner et al. to compute adjusted hazard-ratios that account for multiple correlated markers while evaluating four candidate approaches for missing tumor subtype. We consider the complete case, missing indicator, inverse probability weighting and multiple imputation approaches for missing tumor markers. We evaluate these four approaches using simulation studies and apply each to a real study of breast cancer risk factors considering multiple subtypes.


Authors who are presenting talks have a * after their name.

Back to the full JSM 2015 program





For program information, contact the JSM Registration Department or phone (888) 231-3473.

For Professional Development information, contact the Education Department.

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

2015 JSM Online Program Home