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Activity Number: 500
Type: Contributed
Date/Time: Wednesday, August 12, 2015 : 8:30 AM to 10:20 AM
Sponsor: Section on Medical Devices and Diagnostics
Abstract #317635
Title: Interpretation of Multi-Reader Diagnostic Radiologic Data-Analysis Parameters, with Applications to Simulation Models and Sample Size Estimation
Author(s): Stephen Hillis*
Companies: The University of Iowa
Keywords: Obuchowski-Rockette ; DBM ; diagnostic radiology ; ROC ; multireader ; Roe and Metz
Abstract:

The Obuchowski-Rockette (OR) and the related Dorfman-Berbaum-Metz (DBM) methods have been the most frequently used analysis method for multireader multicase (MRMC) radiologic imaging data, with the DBM method being a special case of the OR method. Understanding the meaning of these parameters is useful for designing and sizing future studies and empirical validation of the MRMC analysis methods. I present formulas that express the OR parameters in terms of the parameters of the Roe and Metz (RM) model for simulating MRMC data. These formulas allow us to determine the OR parameter values that correspond to each of the RM model simulation combinations. We find that the OR correlations and reader and reader-by-modality variance components are essentially independent of case and reader sample size. In addition, the reader and reader-by-modality variance components are also essentially independent of the estimation method (e.g., the variance components will be similar for MLE and trapezoid AUC outcomes.) The error variance is dependent on case sample size but not reader sample size; it is also affected by the type of estimation.


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