Sequential ED-Design for Binary Dose-Response Experiments

• Activity Number: 495
• Type: Contributed
• Date/Time: Wednesday, August 12, 2015 : 8:30 AM to 10:20 AM
• Sponsor: SSC
• Author(s): XIAOLI Yu* and Jiahua Chen and Rollin Brant
• Companies: and The University of British Columbia and The University of British Columbia
• Keywords: Dose-response experiment ; Optimal design ; Two-stage design ; Sequential ; Adaptive ; Up-and-down design

Abstract

In dose-response studies, experiments are often carried out according to optimal designs for the purpose of accurately determining a specific effective dose (ED) level. If the interest is in the dose-response relationship over a range of ED levels, the design should aim to efficiently estimate several levels. In this paper, we propose a two-stage sequential ED-design for this purpose. We use a small number of trials to provide a tentative estimation of the parameters. The dose levels of the subsequent trials are then selected sequentially, based on the latest model information, to maximize the efficiency of the ED estimation. Our simulations indicate that the proposed design compares favorably with existing designs under various scenarios.