JSM 2015 Preliminary Program

Online Program Home
My Program

Abstract Details

Activity Number: 367
Type: Contributed
Date/Time: Tuesday, August 11, 2015 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract #317192 View Presentation
Title: Case Identification and Regression Estimation in Group Testing When Dilution Effect Is Present
Author(s): Dewei Wang* and McMahan S. Christopher and Colin Gallagher
Companies: University of South Carolina and Clemson University and Clemson University
Keywords: Measurement error ; Pooled testing ; Sensitivity ; Specificity
Abstract:

Group testing, through the use of pooling, has been widely implemented as a more efficient means to screen individuals for infectious diseases. Various testing strategies, such as hierarchical and square array-based testing algorithms, have been proposed. In this talk, I will present the comparison of the operating characteristics, including testing efficiency and classification accuracy, of these algorithms for the purpose of case identification, and also provide a general regression estimation framework for modeling all type group testing data. The differences between our approach and the previous ones are the assumptions regarding testing error rates. We relax previously made assumptions by acknowledging the mechanistic structure of the diagnostic assays. By doing this, we are able to account for the dilution effect; i.e., truly positive specimens could be diluted when they are pooled together with many truly negative ones, and thus cannot be detected. This methodology is illustrated by comparing different testing algorithms via the HIV, HBV and HCV data collected form a study involving Irish prisoners.


Authors who are presenting talks have a * after their name.

Back to the full JSM 2015 program





For program information, contact the JSM Registration Department or phone (888) 231-3473.

For Professional Development information, contact the Education Department.

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

2015 JSM Online Program Home