Abstract Details
Activity Number:
|
325
|
Type:
|
Contributed
|
Date/Time:
|
Tuesday, August 11, 2015 : 8:30 AM to 10:20 AM
|
Sponsor:
|
Biopharmaceutical Section
|
Abstract #317156
|
View Presentation
|
Title:
|
General Mixture-Based Gatekeeping Procedures in an Adaptive-Design Setting
|
Author(s):
|
George Kordzakhia* and Alex Dmitrienko and Eiji Ishida
|
Companies:
|
FDA and Quintiles and FDA
|
Keywords:
|
adaptive design ;
gatekeeping procedures ;
multiple testing
|
Abstract:
|
Testing of multiple clinical objectives in clinical trials that employ adaptive designs has recently attracted attention in the multiple comparison literature. This presentation considers a general framework for setting up mixture-based gatekeeping procedures in clinical trials with several decision points. It is assumed that the null hypotheses of interest are grouped into families to reject their clinical importance. The framework supports powerful component procedures applied within each family and serial logical relationships among the null hypotheses in different families. The approach is illustrated by applying it to a common class of multivariate multiplicity problems with multiple sequences of hypotheses. This is a joint work with Alex Dmitrienko and Eiji Ishida.
|
Authors who are presenting talks have a * after their name.
Back to the full JSM 2015 program
|
For program information, contact the JSM Registration Department or phone (888) 231-3473.
For Professional Development information, contact the Education Department.
The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
2015 JSM Online Program Home
ASA Meetings Department
732 North Washington Street, Alexandria, VA 22314
(703) 684-1221 • meetings@amstat.org
Copyright © American Statistical Association.