JSM 2015 Preliminary Program

Online Program Home
My Program

Abstract Details

Activity Number: 421
Type: Contributed
Date/Time: Tuesday, August 11, 2015 : 2:00 PM to 3:50 PM
Sponsor: Section on Bayesian Statistical Science
Abstract #317105 View Presentation
Title: Modeling Pulsatile Hormone Association with Cox Cluster Models
Author(s): Huayu Liu* and Nichole Carlson and Alex Polotsky
Companies: University of Colorado Anshutz Medical Campus and University of Colorado Anshutz Medical Campus and University of Colorado Anshutz Medical Campus
Keywords: Pulsatile hormone association ; Bayesian deconvolution ; Point Process
Abstract:

The human reproductive axis is regulated by the interactions of hormones in the hypothalamic-pituitary-ovarian axis, especially through the regulation of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). These hormones are secreted intermittently in boluses, called pulses. To study HPO hormones, participants undergo a rapid blood sampling protocol (e.g. every 10 minutes for 12 hours). The results are time series of hormone concentrations. Here we consider a joint model of LH and FSH to characterize the biologic associations between the pulses and improve estimation of FSH pulses. We extend the deconvolution model of pulsing hormones to allow an imperfect, temporal association (e.g., FSH pulses are not required to trigger for every LH pulse). We show how a Cox cluster process can be used to model the temporal association between the pulse locations of two hormones. The estimation is conducted using a spatial birth-death Markov chain Monte Carlo algorithm. Both simulation and experimental LH-FSH data are used to exhibit the performance of this approach compared to existing methods.


Authors who are presenting talks have a * after their name.

Back to the full JSM 2015 program





For program information, contact the JSM Registration Department or phone (888) 231-3473.

For Professional Development information, contact the Education Department.

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

2015 JSM Online Program Home