Abstract:
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It has been shown that using Contura Multi-Lumen Balloon (MLB) breast brachytherapy catheter to deliver accelerated partial breast irradiation in patients with early-stage breast cancer achieved statistically significant improvements in dosimetric capabilities compared to central-lumen single-dwell and multidwell treatments (Arthur et al 2013). However, seroma is a common toxicity after this surgery. In a clinical trial, 341 patients received MLB treatment, out of whom more than 32% patients developed seroma after surgery. One of the goals of this clinical trial is to reveal the relationship, if there is any, between the formation of seroma and dosimetric parameters. Logistic regression is used to examine the relationship, and possible predictors include age, treatment target, maximum skin and rib dose, percentage of prescribed dose, and volume of tissue receiving 100, 150, and 200 percent of prescribed dose. Initial investigation shows that maximum skin dose and volume of tissue receiving 200 percent of prescribed dose are potentially associated with formation of seroma. Detailed analysis with the nature of association will be presented in this report.
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