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Activity Number: 325
Type: Contributed
Date/Time: Tuesday, August 11, 2015 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract #316860 View Presentation
Title: Identifying Treatment Responder Group Using Multiple Biomarkers
Author(s): Zhaoling Meng* and Hui Quan and Tianle Chen
Companies: Sanofi-Aventis and Sanofi and Biogen
Keywords: treatment responder ; biomarker selection ; type I error control
Abstract:

Biomarkers hold tremendous promises in modern medicine such as tailoring a therapy to a better patient responder population. It is unlikely one biomarker alone could reflect all pathological processes that are involved in complicated disorders. We present a regression-based approach with multiple biomarkers to identify the better treatment responder group and control type I error rate. The proposed approach is compared to a naive method and a LASSO based method.


Authors who are presenting talks have a * after their name.

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