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Activity Number: 234
Type: Topic Contributed
Date/Time: Monday, August 10, 2015 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract #316503
Title: Recurrent Events Missing Response: When Can We Ignore It? Hypoglycemic Events Analysis via Recurrent Time-to-Event (HEART) Models
Author(s): Haoda Fu*
Companies: Eli Lilly and Company
Keywords: Diabetes ; Hypoglycemic events ; Gamma frailty model ; Missing data ; Recurrent events ; Coarsening at random
Abstract:

Diabetes affects an estimated 29.2 million people in the United States and is one of the leading causes of death. A major safety concern in treating diabetes is the occurrence of hypoglycemic events. Despite this concern, the current methods of analyzing hypoglycemic events, including the Wilcoxon rank sum test and negative binomial regression, are not satisfactory. We developed a gamma frailty recurrent event model. In particular, we provide a simple proof and illustration of the coarsening at random condition so that the practitioner can easily verify this condition. Connections and differences with traditional methods are discussed, and we demonstrate that under certain scenarios the widely used Wilcoxon rank sum test and negative binomial regression cannot control type 1 error rates while our proposed method is robust in all these situations. The usefulness of our method is demonstrated through a diabetes dataset which provides new clinical insights on the hypoglycemic data.


Authors who are presenting talks have a * after their name.

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