JSM 2015 Online Program

Online Program Home
My Program

Abstract Details

Activity Number: 368
Type: Contributed
Date/Time: Tuesday, August 11, 2015 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract #316093
Title: Methods of Assessing Treatment Failure or Response with Informative Censoring
Author(s): Jun Zhao* and Qi Tang and Bo Fu and Claire L. Tsao
Companies: AbbVie and AbbVie and AbbVie and AbbVie
Keywords: longitudinal ; treatment failure ; informative censoring

In longitudinal clinical trials, we may define the onset of treatment response or treatment failure based on assessing relative change on clinical instruments that are commonly used in clinical practices. In some cases, the defined event needs to be confirmed at pre-defined later visit/visits after the event onset. However, when patients drop out of the study early or get an alternative medical intervention after the initial onset of the event, the subsequent clinical assessments are missing or considered as missing for the latter visits. Therefore, the event (either response or failure) cannot be confirmed and the information becomes censored. In this research, we compare several methods that are commonly used to deal with the sustained or confirmed response or failure when the missing data exist and the censoring may be informative. Simulation results are given to illustrate the methods to be applied and the bias introduced is also assessed for the corresponding method.

Authors who are presenting talks have a * after their name.

Back to the full JSM 2015 program

For program information, contact the JSM Registration Department or phone (888) 231-3473.

For Professional Development information, contact the Education Department.

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

2015 JSM Online Program Home