A Model for Time-to-Fracture with a Shock Stream Superimposed on Progressive Degradation: The Study of Osteoporotic Fractures

• Activity Number: 520
• Type: Topic Contributed
• Date/Time: Wednesday, August 12, 2015 : 10:30 AM to 12:20 PM
• Sponsor: Section on Risk Analysis
• Author(s): Xin He* and G.A. Whitmore and Geok Yan Loo and Marc C. Hochberg and Mei-Ling Ting Lee
• Companies: University of Maryland and McGill University and University of Maryland and University of Maryland, Baltimore and University of Maryland
• Keywords: disease progression ; elderly ; first hitting time ; health process ; threshold regression ; time-to-event data

Abstract

Osteoporotic hip fractures in the elderly are associated with a high mortality in the first year following fracture and a high incidence of disability among survivors. We study first and second fractures of elderly women using data from the Study of Osteoporotic Fractures. We present a new conceptual framework, stochastic model, and statistical methodology for time to fracture. Our approach gives additional insights into the patterns for first and second fractures and the concomitant risk factors. Our modeling perspective involves a novel time-to-event methodology called threshold regression, which is based on the plausible idea that many events occur when an underlying process describing the health or condition of a person or system encounters a critical boundary or threshold for the first time. In the parlance of stochastic processes, this time to event is a first hitting time of the threshold. The underlying process in our model is a composite of a chronic degradation process for skeletal health combined with a random stream of shocks from external traumas, which taken together trigger fracture events.